TET inducible expression of the α4β7-integrin ligand MAdCAM-1 on the blood-brain barrier does not influence the immunopathogenesis of experimental autoimmune encephalomyelitis.

@article{Doering2011TETIE,
  title={TET inducible expression of the α4β7-integrin ligand MAdCAM-1 on the blood-brain barrier does not influence the immunopathogenesis of experimental autoimmune encephalomyelitis.},
  author={Axinia Doering and Friederike Pfeiffer and M Meier and B{\'e}n{\'e}dicte Dehouck and Silke Tauber and Urban Deutsch and Britta Engelhardt},
  journal={European journal of immunology},
  year={2011},
  volume={41 3},
  pages={
          813-21
        }
}
Inhibiting the α4 subunit of the integrin heterodimers α4β1 and α4β7 with the mab natalizumab is an effective treatment of multiple sclerosis (MS). Which of the two α4 heterodimers is involved in disease pathogenesis has, however, remained controversial. Whereas the development of experimental autoimmune encephalomyelitis (EAE), an animal model of MS, is ameliorated in β7-integrin-deficient C57BL/6 mice, neutralizing antibodies against the β7-integrin subunit or the α4β7-integrin heterodimer… CONTINUE READING
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