TERT promoter mutations and telomere length in adult malignant gliomas and recurrences

@inproceedings{Heidenreich2015TERTPM,
  title={TERT promoter mutations and telomere length in adult malignant gliomas and recurrences},
  author={Barbara Heidenreich and Panduranga Sivaramakrishna Rachakonda and Ismail Hosen and Florian Volz and Kari Hemminki and Astrid Weyerbrock and Rajiv Kumar},
  booktitle={Oncotarget},
  year={2015}
}
In this report on 303 gliomas we show the highest frequency of TERT promoter mutations in gliobastomas (80%) followed by oligodendrogliomas (70%) and astrocytomas (39%). We observed positive association between TERT promoter and IDH mutations in oligodendroglial tumors (OR = 26.3; 95% CI 2.5-250.2) and inverse association in primary glioblastomas (OR = 0.13; 95% CI 0.03-0.58). Tumors with TERT promoter mutations compared to those without showed increased TERT transcription; we also showed… CONTINUE READING

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