TERT promoter mutation in resectable hepatocellular carcinomas: a strong association with hepatitis C infection and absence of hepatitis B infection.

@article{Chen2014TERTPM,
  title={TERT promoter mutation in resectable hepatocellular carcinomas: a strong association with hepatitis C infection and absence of hepatitis B infection.},
  author={Yu-Ling Chen and Yung-Ming Jeng and Chih-Ning Chang and Hsin-Jung Lee and H Hsu and P Lai and R. N. Yuan},
  journal={International journal of surgery},
  year={2014},
  volume={12 7},
  pages={659-65}
}
INTRODUCTION Mutation in the core promoter of the telomerase reverse transcriptase (TERT) gene was determined to be a frequent event in malignant melanoma and other cancers. However, the role of TERT promoter mutation in hepatocellular carcinomas (HCCs) remains largely unknown. METHODS Genomic DNA samples from the tumor tissue of 195 HCCs were analyzed for TERT promoter mutation at 2 hotspots (-124 and -146 bp from the ATG start site, g.1,295,228 and g.1,295,250, respectively) through direct… CONTINUE READING