TERT promoter hotspot mutations are recurrent in myxoid liposarcomas but rare in other soft tissue sarcoma entities

@inproceedings{Koelsche2014TERTPH,
  title={TERT promoter hotspot mutations are recurrent in myxoid liposarcomas but rare in other soft tissue sarcoma entities},
  author={Christian Koelsche and Marcus Renner and Wolfgang Hartmann and Regine Brandt and Burkhard Lehner and Nina Waldburger and Ingo Alldinger and Thomas L Schmitt and Gerlinde Egerer and Roland Penzel and Eva Wardelmann and Peter Schirmacher and Andreas von Deimling and Gunhild Mechtersheimer},
  booktitle={Journal of experimental & clinical cancer research : CR},
  year={2014}
}
  • Christian Koelsche, Marcus Renner, +11 authors Gunhild Mechtersheimer
  • Published in
    Journal of experimental…
    2014
  • Biology, Medicine
  • BackgroundRecently, recurrent point mutations in the telomerase reverse transcriptase (TERT) promoter region have been found in many human cancers, leading to a new transcription factor binding site, increased induction of TERT and subsequently to telomere maintenance. We determined the prevalence of TERT promoter mutations in soft tissue sarcomas of 341 patients comprising 16 entities and in 16 sarcoma cell lines covering 7 different soft tissue sarcoma types.MethodsThe sarcoma tissue samples… CONTINUE READING

    Create an AI-powered research feed to stay up to date with new papers like this posted to ArXiv

    Citations

    Publications citing this paper.
    SHOWING 1-10 OF 38 CITATIONS

    TERT promoter mutations are rare in bone and soft tissue sarcomas of Japanese patients.

    VIEW 15 EXCERPTS
    CITES RESULTS & BACKGROUND
    HIGHLY INFLUENCED

    Massively Parallel Sequencing of Gene Fusion-Associated Sarcomas

    VIEW 44 EXCERPTS
    CITES BACKGROUND
    HIGHLY INFLUENCED

    TERT Promoter Mutations in Soft Tissue Sarcomas

    VIEW 6 EXCERPTS
    CITES BACKGROUND
    HIGHLY INFLUENCED

    Molecular changes in solitary fibrous tumor progression

    VIEW 1 EXCERPT
    CITES BACKGROUND

    Revisiting Telomere Shortening in Cancer

    VIEW 1 EXCERPT
    CITES BACKGROUND

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 54 REFERENCES

    TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal.

    VIEW 4 EXCERPTS
    HIGHLY INFLUENTIAL

    The role of telomere biology in cancer.

    VIEW 12 EXCERPTS
    HIGHLY INFLUENTIAL