TEL deletion analysis supports a novel view of relapse in childhood acute lymphoblastic leukemia.

@article{Zuna2004TELDA,
  title={TEL deletion analysis supports a novel view of relapse in childhood acute lymphoblastic leukemia.},
  author={Jan Zuna and Anthony M. Ford and Martina Peham and Naina Patel and Vaskar Saha and Cornelia Eckert and Joachim Koechling and Renate E Panzer-Gr{\"u}mayer and Jan Trka and Mel Greaves},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2004},
  volume={10 16},
  pages={5355-60}
}
PURPOSE TEL (ETV6)-AML1 (RUNX1) chimeric gene fusions are frequent genetic abnormalities in childhood acute lymphoblastic leukemia (ALL). They often arise prenatally as early events or initiating events and are complemented by secondary postnatal genetic events of which deletion of the non-rearranged, second TEL allele is the most common. This consistent sequence of molecular pathogenesis facilitates an analysis of the clonal origins of relapse in this leukemia, which has some unusual clinical… CONTINUE READING

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