TEL-JAK2 mediates constitutive activation of the phosphatidylinositol 3'-kinase/protein kinase B signaling pathway.

@article{Nguyen2001TELJAK2MC,
  title={TEL-JAK2 mediates constitutive activation of the phosphatidylinositol 3'-kinase/protein kinase B signaling pathway.},
  author={Melody H-H Nguyen and Jenny M-Y Ho and Bryan K. Beattie and Dwayne L. Barber},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 35},
  pages={32704-13}
}
A subset of chromosomal translocations that participate in leukemia involve activated tyrosine kinases. The ets transcription factor, TEL, undergoes translocations with several distinct tyrosine kinases including JAK2. TEL-JAK2 transforms cell lines to factor independence, and constitutive tyrosine kinase activity results in the phosphorylation of several substrates including STAT1, STAT3, and STAT5. In this study we have shown that TEL-JAK2 can constitutively activate the phosphatidylinositol… CONTINUE READING

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