TEL/AML-1 dimerizes and is associated with a favorable outcome in childhood acute lymphoblastic leukemia.

@article{McLean1996TELAML1DA,
  title={TEL/AML-1 dimerizes and is associated with a favorable outcome in childhood acute lymphoblastic leukemia.},
  author={Thomas W. McLean and Sarah M Ringold and Donna S Neuberg and Kimberly Stegmaier and Ramana Tantravahi and Jerome Ritz and H Phillip Koeffler and Seisho Takeuchi and J. W. Janssen and Taku Seriu and Claus Rainer Bartram and Stephen E. Sallan and Dwight Gary Gilliland and Todd R. Golub},
  journal={Blood},
  year={1996},
  volume={88 11},
  pages={4252-8}
}
Polymerase chain reaction-based screening of childhood acute lymphoblastic leukemia (ALL) samples showed that a TEL/AML1 fusion transcript was detected in 27% of all cases, representing the most common known gene rearrangement in childhood cancer. The TEL/AML1 fusion results from a t(12;21)(p13;q22) chromosomal translocation, but was undetectable at the routine cytogenetic level. TEL/AML1-positive patients had exclusively B-lineage ALL, and most patients were between the ages of 2 and 9 years… CONTINUE READING
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