TEFM (c17orf42) is necessary for transcription of human mtDNA

  title={TEFM (c17orf42) is necessary for transcription of human mtDNA},
  author={Michal Minczuk and Jiuya He and Anna M. Duch and Thijs J G Ettema and Aleksander Chlebowski and Karol Dzionek and Leo G. J. Nijtmans and Martijn A. Huynen and Ian Holt},
  booktitle={Nucleic acids research},
Here we show that c17orf42, hereafter TEFM (transcription elongation factor of mitochondria), makes a critical contribution to mitochondrial transcription. Inactivation of TEFM in cells by RNA interference results in respiratory incompetence owing to decreased levels of H- and L-strand promoter-distal mitochondrial transcripts. Affinity purification of TEFM from human mitochondria yielded a complex comprising mitochondrial transcripts, mitochondrial RNA polymerase (POLRMT), pentatricopeptide… CONTINUE READING
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