TEF-1 and MEF2 transcription factors interact to regulate muscle-specific promoters.

@article{Maeda2002TEF1AM,
  title={TEF-1 and MEF2 transcription factors interact to regulate muscle-specific promoters.},
  author={Tomoji Maeda and M. V. N. V. Prasad Gupta and Alexandre F. R. Stewart},
  journal={Biochemical and biophysical research communications},
  year={2002},
  volume={294 4},
  pages={791-7}
}
Many muscle-specific genes are regulated by transcriptional enhancer factor-1 (TEF-1), serum response factor (SRF), and myocyte enhancer factor-2 (MEF2) transcription factors. TEF-1 interacts with the MADS domain of SRF and together SRF and TEF-1 co-activate the skeletal alpha-actin promoter. MEF2 factors also contain a MADS domain with 50% amino acid identity to the SRF MADS domain. Because of this sequence divergence, some SRF co-factors do not interact with MEF2. To demonstrate that TEF-1… CONTINUE READING

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