TEADs Mediate Nuclear Retention of TAZ to Promote Oncogenic Transformation*

@article{Chan2009TEADsMN,
  title={TEADs Mediate Nuclear Retention of TAZ to Promote Oncogenic Transformation*},
  author={S. W. Chan and C. J. Lim and L. S. Loo and Y. F. Chong and Caixia Huang and W. Hong},
  journal={Journal of Biological Chemistry},
  year={2009},
  volume={284},
  pages={14347 - 14358}
}
  • S. W. Chan, C. J. Lim, +3 authors W. Hong
  • Published 2009
  • Medicine, Biology
  • Journal of Biological Chemistry
    • The transcriptional coactivators YAP and TAZ are downstream targets inhibited by the Hippo tumor suppressor pathway. The expression level of TAZ is recently shown to be elevated in invasive breast cancer cells and some primary breast cancers. TAZ is important for breast cancer cell migration, invasion, and tumorigenesis, but the underlying mechanism is not defined. In this study, we show that TAZ interacts with TEAD transcriptional factors. Knockdown of TEADs suppresses TAZ-mediated oncogenic… CONTINUE READING
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    Background Citations
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    207 Citations
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    References

    SHOWING 1-10 OF 65 REFERENCES
    TAZ Promotes Cell Proliferation and Epithelial-Mesenchymal Transition and Is Inhibited by the Hippo Pathway
    • 711
    • PDF
    TEAD mediates YAP-dependent gene induction and growth control.
    • 1,538
    • PDF
    A role for TAZ in migration, invasion, and tumorigenesis of breast cancer cells.
    • 407
    • PDF
    Both TEAD-binding and WW domains are required for the growth stimulation and oncogenic transformation activity of yes-associated protein.
    • 162
    • PDF
    Mammalian Tead proteins regulate cell proliferation and contact inhibition as transcriptional mediators of Hippo signaling
    • 337
    • PDF
    Negative regulation of YAP by LATS1 underscores evolutionary conservation of the Drosophila Hippo pathway.
    • 233
    • PDF
    Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control.
    • 1,958
    • PDF
    TAZ Promotes PC2 Degradation through a SCFβ-Trcp E3 Ligase Complex
    • 167
    • PDF
    TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal
    • 537
    TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasm.
    • 570
    • PDF