TEADs Mediate Nuclear Retention of TAZ to Promote Oncogenic Transformation*

  title={TEADs Mediate Nuclear Retention of TAZ to Promote Oncogenic Transformation*},
  author={S. W. Chan and C. J. Lim and L. S. Loo and Y. F. Chong and Caixia Huang and W. Hong},
  journal={Journal of Biological Chemistry},
  pages={14347 - 14358}
  • S. W. Chan, C. J. Lim, +3 authors W. Hong
  • Published 2009
  • Medicine, Biology
  • Journal of Biological Chemistry
  • The transcriptional coactivators YAP and TAZ are downstream targets inhibited by the Hippo tumor suppressor pathway. The expression level of TAZ is recently shown to be elevated in invasive breast cancer cells and some primary breast cancers. TAZ is important for breast cancer cell migration, invasion, and tumorigenesis, but the underlying mechanism is not defined. In this study, we show that TAZ interacts with TEAD transcriptional factors. Knockdown of TEADs suppresses TAZ-mediated oncogenic… CONTINUE READING
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