TDP1 and PARP1 deficiency are cytotoxic to rhabdomyosarcoma cells.

@article{Fam2013TDP1AP,
  title={TDP1 and PARP1 deficiency are cytotoxic to rhabdomyosarcoma cells.},
  author={Hok Khim Fam and Cheryl Walton and Sheetal A. Mitra and Miraj Kobad Chowdhury and Nichola Osborne and Kunho Choi and Guobin Sun and Patrick Wong and Maureen J. O’Sullivan and Gulisa Turashvili and S. Ferrer Aparicio and Timothy Triche and Mason Bond and Catherine J Pallen and Cornelius F. Boerkoel},
  journal={Molecular cancer research : MCR},
  year={2013},
  volume={11 10},
  pages={
          1179-92
        }
}
UNLABELLED Rhabdomyosarcoma is the most common soft tissue sarcoma in children. Metastatic rhabdomyosarcoma in children has a 5-year event-free survival rate of <30%, and a recent clinical trial with irinotecan, a topoisomerase I inhibitor, failed to improve outcome. Therefore, it was surmised that failure of irinotecan may be the result of overexpression of the DNA repair enzyme tyrosyl-DNA phosphodiesterase (TDP1), which processes topoisomerase I-DNA complexes resulting from topoisomerase I… CONTINUE READING
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