TDP-43-positive white matter pathology in frontotemporal lobar degeneration with ubiquitin-positive inclusions.

@article{Neumann2007TDP43positiveWM,
  title={TDP-43-positive white matter pathology in frontotemporal lobar degeneration with ubiquitin-positive inclusions.},
  author={Manuela Neumann and Linda K. Kwong and Adam C Truax and Ben Vanmassenhove and Hans A. Kretzschmar and Vivianna M Van Deerlin and Chrisopher M Clark and Murray Grossman and Bruce L. Miller and John Q. Trojanowski and Virginia M-Y Lee},
  journal={Journal of neuropathology and experimental neurology},
  year={2007},
  volume={66 3},
  pages={177-83}
}
TDP-43 was recently identified as the major disease protein in neuronal inclusions in frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U). TDP-43 is not only linked to disease mechanisms in FTLD-U, but it is also the most robust marker for the specific detection of neuronal inclusions in FTLD-U. In this study, we describe additional TDP-43 pathology in the white matter as a characteristic feature in a series of 38 FTLD-U cases including 3 cases with mutations in the… CONTINUE READING

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References

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Showing 1-10 of 29 references

Nuclear factor TDP-43 binds to the polymorphic TG repeats in CFTR intron 8 and causes skipping of Neumann et al

E Buratti, A Brindisi, F Pagani
J Neuropathol Exp Neurol Volume 66, • 2007

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