TDP-43 is recruited to stress granules in conditions of oxidative insult.

@article{Colombrita2009TDP43IR,
  title={TDP-43 is recruited to stress granules in conditions of oxidative insult.},
  author={Claudia Colombrita and Eleonora Zennaro and Claudia Fallini and Markus Weber and Andreas Sommacal and Emanuele Buratti and Vincenzo Silani and Antonia Ratti},
  journal={Journal of neurochemistry},
  year={2009},
  volume={111 4},
  pages={
          1051-61
        }
}
Transactive response DNA-binding protein 43 (TDP-43) forms abnormal ubiquitinated and phosphorylated inclusions in brain tissues from patients with amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration. TDP-43 is a DNA/RNA-binding protein involved in RNA processing, such as transcription, pre-mRNA splicing, mRNA stabilization and transport to dendrites. We found that in response to oxidative stress and to environmental insults of different types TDP-43 is capable to assemble… CONTINUE READING
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