TDP-43 binds heterogeneous nuclear ribonucleoprotein A/B through its C-terminal tail: an important region for the inhibition of cystic fibrosis transmembrane conductance regulator exon 9 splicing.

@article{Buratti2005TDP43BH,
  title={TDP-43 binds heterogeneous nuclear ribonucleoprotein A/B through its C-terminal tail: an important region for the inhibition of cystic fibrosis transmembrane conductance regulator exon 9 splicing.},
  author={Emanuele Buratti and Antonia Brindisi and Maurizio Giombi and Sergio Tisminetzky and Youhna M. Ayala and Francisco E. Baralle},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 45},
  pages={37572-84}
}
TDP-43 is a highly conserved nuclear factor of yet unknown function that binds to ug-repeated sequences and is responsible for cystic fibrosis transmembrane conductance regulator exon 9 splicing inhibition. We have analyzed TDP-43 interactions with other splicing factors and identified the critical regions for the protein/protein recognition events that determine this biological function. We show here that the C-terminal region of TDP-43 is capable of binding directly to several proteins of the… CONTINUE READING
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