TDP-43 as a possible biomarker for frontotemporal lobar degeneration: a systematic review of existing antibodies

@inproceedings{Goossens2015TDP43AA,
  title={TDP-43 as a possible biomarker for frontotemporal lobar degeneration: a systematic review of existing antibodies},
  author={Joery Goossens and Eugeen Vanmechelen and John Q. Trojanowski and Virginia M-Y Lee and Christine Van Broeckhoven and Julie van der Zee and Sebastiaan Engelborghs},
  booktitle={Acta neuropathologica communications},
  year={2015}
}
Frontotemporal lobar degeneration (FTLD) is one of the leading causes of dementia after Alzheimer's disease. A high-ranking candidate to become a diagnostic marker for a major pathological subtype of FTLD is the transactive response DNA binding protein of 43 kDa (TDP-43). The main objective is to elucidate which antibodies are specific for pathological TDP-43, with special interest in its modified isoforms. Indeed, TDP-43 has been shown to be hyperphosphorylated and truncated in disease. A… CONTINUE READING

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