TDP-43 accumulation is common in myopathies with rimmed vacuoles

Abstract

TAR-DNA-binding protein-43 (TDP-43) is a nuclear protein that is thought to play a regulatory role in gene expression. Ubiquitinated TDP-43 is found in cytoplasmic inclusions in motor neuron disease (MND), frontotemporal lobar degeneration (FTLD-TDP), and MND with FTLD [4]. This shared histopathological hallmark led to the classiWcation of a new class of… (More)
DOI: 10.1007/s00401-008-0471-2

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Cite this paper

@article{Kuesters2008TDP43AI, title={TDP-43 accumulation is common in myopathies with rimmed vacuoles}, author={Benno Kuesters and Bas van Hoeve and Helenius Jurgen Schelhaas and Henk J Ter Laak and Baziel G. M. van Engelen and Martin Lammens}, journal={Acta Neuropathologica}, year={2008}, volume={117}, pages={209-211} }