TDP-43 Identified from a Genome Wide RNAi Screen for SOD1 Regulators

  title={TDP-43 Identified from a Genome Wide RNAi Screen for SOD1 Regulators},
  author={Balajee R. Somalinga and Cameron E. Day and Shuguang Wei and Michael G. Roth and Philip J. Thomas},
  booktitle={PloS one},
Amyotrophic Lateral Sclerosis (ALS) is a late-onset, progressive neurodegenerative disease affecting motor neurons in the brain stem and spinal cord leading to loss of voluntary muscular function and ultimately, death due to respiratory failure. A subset of ALS cases are familial and associated with mutations in superoxide dismutase 1 (SOD1) that destabilize the protein and predispose it to aggregation. In spite of the fact that sporadic and familial forms of ALS share many common patho… CONTINUE READING


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