TDP-43: a novel neurodegenerative proteinopathy.

  title={TDP-43: a novel neurodegenerative proteinopathy.},
  author={Mark S. Forman and John Q. Trojanowski and Virginia M-Y Lee},
  journal={Current opinion in neurobiology},
  volume={17 5},
Over the past decade, it has become clear that there is a significant overlap in the clinical spectrum of frontotemporal lobar degeneration and amyotrophic lateral sclerosis (ALS). The identification of TDP-43 as the major disease protein in the pathology of both frontotemporal lobar degeneration with ubiquitin inclusions and ALS provides the first molecular link for these diseases. Pathological TDP-43 is abnormally phosphorylated, ubiquitinated, and cleaved to generate carboxy-terminal… CONTINUE READING
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