TDP-43: a novel neurodegenerative proteinopathy.

@article{Forman2007TDP43AN,
  title={TDP-43: a novel neurodegenerative proteinopathy.},
  author={Mark S. Forman and John Q. Trojanowski and Virginia M-Y Lee},
  journal={Current opinion in neurobiology},
  year={2007},
  volume={17 5},
  pages={548-55}
}
Over the past decade, it has become clear that there is a significant overlap in the clinical spectrum of frontotemporal lobar degeneration and amyotrophic lateral sclerosis (ALS). The identification of TDP-43 as the major disease protein in the pathology of both frontotemporal lobar degeneration with ubiquitin inclusions and ALS provides the first molecular link for these diseases. Pathological TDP-43 is abnormally phosphorylated, ubiquitinated, and cleaved to generate carboxy-terminal… CONTINUE READING
51 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 51 extracted citations

Similar Papers

Loading similar papers…