TDP-43, an ALS Linked Protein, Regulates Fat Deposition and Glucose Homeostasis


The identification of proteins which determine fat and lean body mass composition is critical to better understanding and treating human obesity. TDP-43 is a well-conserved RNA-binding protein known to regulate alternative splicing and recently implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS). While TDP-43 knockout mice show early… (More)
DOI: 10.1371/journal.pone.0071793


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