TDAG8, TRPV1, and ASIC3 involved in establishing hyperalgesic priming in experimental rheumatoid arthritis

@inproceedings{Hsieh2017TDAG8TA,
  title={TDAG8, TRPV1, and ASIC3 involved in establishing hyperalgesic priming in experimental rheumatoid arthritis},
  author={Wei-Shan Hsieh and Chia-Chi Kung and Shir-Ly Huang and Shih-Chang Lin and Wei-Hsin Sun},
  booktitle={Scientific Reports},
  year={2017}
}
Rheumatoid arthritis (RA), characterized by chronic inflammation of synovial joints, is often associated with ongoing pain and increased pain sensitivity. High hydrogen ion concentration (acidosis) found in synovial fluid in RA patients is associated with disease severity. Acidosis signaling acting on proton-sensing receptors may contribute to inflammation and pain. Previous studies focused on the early phase of arthritis (<5 weeks) and used different arthritis models, so elucidating the roles… CONTINUE READING
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