TCS: a new multiple sequence alignment reliability measure to estimate alignment accuracy and improve phylogenetic tree reconstruction.

@article{Chang2014TCSAN,
  title={TCS: a new multiple sequence alignment reliability measure to estimate alignment accuracy and improve phylogenetic tree reconstruction.},
  author={Jia-Ming Chang and Paolo Di Tommaso and Cedric Notredame},
  journal={Molecular biology and evolution},
  year={2014},
  volume={31 6},
  pages={1625-37}
}
Multiple sequence alignment (MSA) is a key modeling procedure when analyzing biological sequences. Homology and evolutionary modeling are the most common applications of MSAs. Both are known to be sensitive to the underlying MSA accuracy. In this work, we show how this problem can be partly overcome using the transitive consistency score (TCS), an extended version of the T-Coffee scoring scheme. Using this local evaluation function, we show that one can identify the most reliable portions of an… CONTINUE READING
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Using multiple alignment methods to assess the quality of genomic data analysis

  • C Notredame, C. Abergel
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