TCR signaling intensity controls CD8+ T cell responsiveness to TGF-β.

  title={TCR signaling intensity controls CD8+ T cell responsiveness to TGF-β.},
  author={Vidhyalakshmi Arumugam and Theresa Bluemn and Erin M Wesley and Amanda M. Schmidt and Taku Kambayashi and Subramaniam Malarkannan and Matthew J. Riese},
  journal={Journal of leukocyte biology},
  volume={98 5},
DGK-ζ is a negative regulator of TCR signaling that causes degradation of the second messenger DAG, terminating DAG-mediated activation of Ras and PKCθ. Cytotoxic T cells deficient in DGK-ζ demonstrate enhanced effector functions in vitro and antitumor activity in vivo, perhaps because of insensitivity to inhibitory cytokines. We sought to determine whether the enhanced responsiveness of DGK-ζ-deficient T cells renders them insensitive to the inhibitory cytokine TGF-β and to determine how the… CONTINUE READING
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