TCR repertoire and Foxp3 expression define functionally distinct subsets of CD4+ regulatory T cells.

@article{Kuczma2009TCRRA,
  title={TCR repertoire and Foxp3 expression define functionally distinct subsets of CD4+ regulatory T cells.},
  author={Michal P. Kuczma and Iwona Pawlikowska and Magdalena Kopij and Robert Podolsky and Grzegorz A. Rempala and Piotr Kraj},
  journal={Journal of immunology},
  year={2009},
  volume={183 5},
  pages={
          3118-29
        }
}
Despite extensive research efforts to characterize peripheral regulatory T (T(reg)) cells expressing transcription factor Foxp3, their subset complexity, phenotypic characteristics, TCR repertoire and Ag specificities remain ambiguous. In this study, we identify and define two subsets of peripheral T(reg) cells differing in Foxp3 expression level and TCR repertoires. T(reg) cells expressing a high level of Foxp3 and TCRs not used by naive CD4(+) T cells present a stable suppressor phenotype and… CONTINUE READING
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