TCR clonotypes modulate the protective effect of HLA class I molecules in HIV-1 infection

  title={TCR clonotypes modulate the protective effect of HLA class I molecules in HIV-1 infection},
  author={Huabiao Chen and Zaza M. Ndhlovu and Dongfang Liu and Lindsay C Porter and Justin W. Fang and Sam Darko and Mark A Brockman and Toshiyuki Miura and Zabrina L. Brumme and Arne Schneidewind and Alicja Piechocka-Trocha and Kevin T Cesa and Jennifer Sela and Thai Duong Hong Cung and Ildik{\'o} T{\'o}th and Florencia Pereyra and Xu G. Yu and Daniel C. Douek and Daniel E Kaufmann and Todd M. Allen and Bruce D. Walker},
  journal={Nature Immunology},
The human leukocyte antigens HLA-B*27 and HLA-B*57 are associated with protection against progression of disease that results from infection with human immunodeficiency virus type 1 (HIV-1), yet most people with alleles encoding HLA-B*27 and HLA-B*57 are unable to control HIV-1. Here we found that HLA-B*27-restricted CD8+ T cells in people able to control infection with HIV-1 (controllers) and those who progress to disease after infection with HIV-1 (progressors) differed in their ability to… CONTINUE READING
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