TCR beta-chain sharing in human CD8+ T cell responses to cytomegalovirus and EBV.

@article{Venturi2008TCRBS,
  title={TCR beta-chain sharing in human CD8+ T cell responses to cytomegalovirus and EBV.},
  author={Vanessa Venturi and Hui Yee Chin and Tedi E. Asher and Kristin Ladell and Phillip Scheinberg and Ethan R Bornstein and David van Bockel and Anthony D. Kelleher and Daniel C. Douek and David A. Price and Miles P. Davenport},
  journal={Journal of immunology},
  year={2008},
  volume={181 11},
  pages={7853-62}
}
The CD8(+) TCR repertoires specific for many immunogenic epitopes of CMV and EBV are dominated by a few TCR clonotypes and involve public TCRs that are shared between many MHC-matched individuals. In previous studies, we demonstrated that the observed sharing of epitope-specific TCRbeta chains between individuals is strongly associated with TCRbeta production frequency, and that a process of convergent recombination facilitates the more efficient production of some TCRbeta sequences. In this… CONTINUE READING

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