TCR- and CD28-mediated recruitment of phosphodiesterase 4 to lipid rafts potentiates TCR signaling.

@article{Abrahamsen2004TCRAC,
  title={TCR- and CD28-mediated recruitment of phosphodiesterase 4 to lipid rafts potentiates TCR signaling.},
  author={Hilde Abrahamsen and George S Baillie and Jacob Ngai and Torkel Vang and Konstantina Nika and Anja Ruppelt and Tomas M. Mustelin and Manuela Zaccolo and Miles D Houslay and Kjetil Task{\'e}n},
  journal={Journal of immunology},
  year={2004},
  volume={173 8},
  pages={4847-58}
}
Ligation of the TCR along with the coreceptor CD28 is necessary to elicit T cell activation in vivo, whereas TCR triggering alone does not allow a full T cell response. Upon T cell activation of human peripheral blood T cells, we found that the majority of cAMP was generated in T cell lipid rafts followed by activation of protein kinase A. However, upon TCR and CD28 coligation, beta-arrestin in complex with cAMP-specific phosphodiesterase 4 (PDE4) was recruited to lipid rafts which down… CONTINUE READING