TCR Signaling: Mechanisms of Initiation and Propagation.

  title={TCR Signaling: Mechanisms of Initiation and Propagation.},
  author={Adam H Courtney and Wan-Lin Lo and Arthur Weiss},
  journal={Trends in biochemical sciences},
  volume={43 2},
The mechanisms by which a T cell detects antigen using its T cell antigen receptor (TCR) are crucial to our understanding of immunity and the harnessing of T cells therapeutically. A hallmark of the T cell response is the ability of T cells to quantitatively respond to antigenic ligands derived from pathogens while remaining inert to similar ligands derived from host tissues. Recent studies have revealed exciting properties of the TCR and the behaviors of its signaling effectors that are used… CONTINUE READING

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