TCR/CD3 mediated stop-signal is decoupled in T-cells from Ctla4 deficient mice.

@article{Downey2008TCRCD3MS,
  title={TCR/CD3 mediated stop-signal is decoupled in T-cells from Ctla4 deficient mice.},
  author={Jos Downey and Andrew Lloyd Smith and Helga Schneider and Nancy Hogg and Christopher E Rudd},
  journal={Immunology letters},
  year={2008},
  volume={115 1},
  pages={
          70-2
        }
}
CTLA-4 is a co-receptor that plays a pivotal role in regulating the threshold for T-cell activation. We recently reported that CTLA-4 ligation can over-ride the stop-signal induced by anti-CD3 ligation [Schneider H, Downey J, Smith A, Zinselmeyer BH, Rush C, Brewer JM, et al. Reversal of the TCR stop-signal by CTLA-4. Science 2006;313:1972]. While these studies compared CTLA-4 positive and negative T-cells from normal mice, little is known regarding the behaviour of T-cells from diseased Ctla4… CONTINUE READING

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