TCR+/BCR+ dual-expressing cells and their associated public BCR clonotype are not enriched in type 1 diabetes

@article{Japp2021TCRBCRDC,
  title={TCR+/BCR+ dual-expressing cells and their associated public BCR clonotype are not enriched in type 1 diabetes},
  author={Alberto Sada Japp and Wenzhao Meng and Aaron M. Rosenfeld and D. Perry and Puchong Thirawatananond and Rhonda Bacher and Chengyang Liu and Jay Gardner and Mark A. Atkinson and Klaus H. Kaestner and Todd M. Brusko and Ali Naji and Eline T. Luning Prak and Michael R. Betts},
  journal={Cell},
  year={2021},
  volume={184},
  pages={827-839.e14}
}
4 Citations
CD5‐expressing CD8+ T‐cell subsets differ between children with type 1 diabetes and controls
TLDR
Comparisons of conventional immune cells detected increased proportions of CD3+ T cells in T1D patients, whereas CD19+ B‐cell proportions were comparable to controls, and in vitro experiments showed stable CD5 expression differences of CD8- T cells after T‐cell activation, cytokine stimulation and culture.
Insights From Single Cell RNA Sequencing Into the Immunology of Type 1 Diabetes- Cell Phenotypes and Antigen Specificity
TLDR
A review of the first papers to use scRNAseq to characterise human lymphocyte phenotypes in T1D in the peripheral blood, pancreatic lymph nodes and islets to identify novel biomarkers and targets for immunotherapy.
Single cell based high-throughput Ig and TCR repertoire sequencing analysis in rhesus macaques
TLDR
The ability to perform high-throughput immune repertoire analysis in rhesus macaques at the single cell level is established.

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