TCL1 participates in early embryonic development and is overexpressed in human seminomas.

@article{Narducci2002TCL1PI,
  title={TCL1 participates in early embryonic development and is overexpressed in human seminomas.},
  author={Maria Grazia Narducci and Maria Teresa Fiorenza and Sang-Moo Kang and Arturo Bevilacqua and Monica Di Giacomo and Daniele Remotti and Maria Cristina Picchio and Vincenzo Fidanza and Max D. Cooper and Carlo M. Croce and Franco Mangia and Giandomenico Russo},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2002},
  volume={99 18},
  pages={
          11712-7
        }
}
Overexpression of the TCL1 oncogene has been shown to play a causative role in T cell leukemias of humans and mice. The characterization of Tcl1-deficient mice in these studies indicates an important developmental role for Tcl1 in early embryogenesis. In wild-type embryos, Tcl1 is abundant in the first three mitotic cycles, during which it shuttles between nuclei and the embryo cortical regions in a cell-cycle-dependent fashion. The absence of this protein in early embryogenesis results in… CONTINUE READING

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