TCF7L2 variants associate with CKD progression and renal function in population-based cohorts.

@article{Kttgen2008TCF7L2VA,
  title={TCF7L2 variants associate with CKD progression and renal function in population-based cohorts.},
  author={Anna K{\"o}ttgen and S. -Y. Hwang and Evadnie Rampersaud and Josef Coresh and Kari E. North and James S. Pankow and James B. Meigs and Jose C Florez and Afshin Parsa and Daniel L{\'e}vy and Eric Boerwinkle and Alan R. Shuldiner and Caroline Fox and W. H. Kao},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2008},
  volume={19 10},
  pages={1989-99}
}
Genetic variants may increase susceptibility to both diabetes and kidney disease. Whether known diabetes-associated variants in the transcription factor 7-like 2 (TCF7L2) gene are associated with chronic kidney disease (CKD) progression and markers of kidney function is unknown. Participants of the Atherosclerosis Risk in Communities Study (ARIC; n = 11,061 self-identified white and n = 4014 black), Framingham Heart Offspring Cohort (FHS; n = 2468), and Heredity and Phenotype Intervention Heart… CONTINUE READING

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