TCF7L2 polymorphisms modulate proinsulin levels and beta-cell function in a British Europid population.

@article{Loos2007TCF7L2PM,
  title={TCF7L2 polymorphisms modulate proinsulin levels and beta-cell function in a British Europid population.},
  author={Ruth J F Loos and Paul W Franks and Richard W Francis and In{\^e}s Barroso and Fiona Mary Gribble and David B Savage and Ken K Ong and Stephen O'Rahilly and Nicholas J Wareham},
  journal={Diabetes},
  year={2007},
  volume={56 7},
  pages={1943-7}
}
Rapidly accumulating evidence shows that common T-cell transcription factor (TCF)7L2 polymorphisms confer risk of type 2 diabetes through unknown mechanisms. We examined the association between four TCF7L2 single nucleotide polymorphisms (SNPs), including rs7903146, and measures of insulin sensitivity and insulin secretion in 1,697 Europid men and women of the population-based MRC (Medical Research Council)-Ely study. The T-(minor) allele of rs7903146 was strongly and positively associated with… CONTINUE READING

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