TCF7L2 and Glucose Metabolism: Time to Look Beyond the Pancreas

  title={TCF7L2 and Glucose Metabolism: Time to Look Beyond the Pancreas},
  author={Marcelo A. Nobrega},
Noncoding genetic variation in the locus encoding for the Wnt signaling effector TCF7L2 remains the strongest genetic determinant of type 2 diabetes (T2D) risk in humans. This association raises the hypothesis that disease variants alter the quantitative, spatial, and/or temporal expression patterns of this gene. Understanding the mechanisms by which TCF7L2 and Wnt signaling regulate glucose metabolism may reveal novel insights into the pathogenesis of T2D, as well as highlight cellular and… CONTINUE READING
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