TCF7L2 Regulates Late Events in Insulin Secretion From Pancreatic Islet β-Cells

@inproceedings{Xavier2009TCF7L2RL,
  title={TCF7L2 Regulates Late Events in Insulin Secretion From Pancreatic Islet β-Cells},
  author={Gabriela da Silva Xavier and Merewyn K. Loder and Angela McDonald and Andrei I Tarasov and Raffaella Carzaniga and Katrin Kronenberger and Sebastian Barg and Guy A. Rutter},
  booktitle={Diabetes},
  year={2009}
}
OBJECTIVE Polymorphisms in the human TCF7L2 gene are associated with reduced insulin secretion and an increased risk of type 2 diabetes. However, the mechanisms by which TCF7L2 affect insulin secretion are still unclear. We define the effects of TCF7L2 expression level on mature beta-cell function and suggest a potential mechanism for its actions. RESEARCH DESIGN AND METHODS TCF7L2 expression in rodent islets and beta-cell lines was altered using RNAi or adenoviral transduction. Beta-cell… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 46 REFERENCES

Dual modes of Munc18-1/SNARE interactions are coupled by functionally critical binding to syntaxin-1 N terminus.

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 2007
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Transcription factor 7-like 2 polymorphism and colon cancer.

  • Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • 2008
VIEW 1 EXCERPT