TCF1 and beta-catenin regulate T cell development and function.

  title={TCF1 and beta-catenin regulate T cell development and function.},
  author={Qing Yu and Archna Sharma and Jyoti Misra Sen},
  journal={Immunologic research},
  volume={47 1-3},
T cell factor-1 (TCF1) critically regulates T cell development. However, signals that control TCF1 function in developing and mature T cells remain unknown. TCF1 along with beta-catenin activates gene transcription and in cooperation with Groucho family of proteins mediates gene repression. It has been established that the beta-catenin-dependent gene expression is often downstream of the canonical Wnt signaling pathway. We have genetically manipulated the beta-catenin gene and generated mutant… CONTINUE READING