TCF1+ hepatitis C virus-specific CD8+ T cells are maintained after cessation of chronic antigen stimulation

@inproceedings{Wieland2017TCF1HC,
  title={TCF1+ hepatitis C virus-specific CD8+ T cells are maintained after cessation of chronic antigen stimulation},
  author={Dominik Wieland and Janine Kemming and Anita Schuch and F Emmerich and Percy A Knolle and Christoph Neumann-Haefelin and Werner Held and Dietmar Zehn and Maike Hofmann and Robert Thimme},
  booktitle={Nature communications},
  year={2017}
}
Differentiation and fate of virus-specific CD8+ T cells after cessation of chronic antigen stimulation is unclear. Here we show that a TCF1+CD127+PD1+ hepatitis C virus (HCV)-specific CD8+ T-cell subset exists in chronically infected patients with phenotypic features of T-cell exhaustion and memory, both before and after treatment with direct acting antiviral (DAA) agents. This subset is maintained during, and for a long duration after, HCV elimination. After antigen re-challenge the less… CONTINUE READING
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