TCEB1-mutated Renal Cell Carcinoma: A Distinct Genomic and Morphologic Subtype

  title={TCEB1-mutated Renal Cell Carcinoma: A Distinct Genomic and Morphologic Subtype},
  author={Abraham Ari Hakimi and Satish K. Tickoo and Anders S. Jacobsen and Judy Sarungbam and John P. Sfakianos and Yusuke Sato and Teppei Morikawa and Haruki Kume and Masashi Fukayama and Yukio Homma and Alexander I Sankin and R. D. P. Mano and Jonathan A. Coleman and Paul Russo and Seishi Ogawa and Chris Sander and James J Hsieh and Victor E. Reuter},
  booktitle={Modern Pathology},
Integrated sequencing analysis identified a group of tumors among clear cell renal cell carcinomas characterized by hotspot mutations in TCEB1 (a gene that contributes to the VHL complex to ubiquitinate hypoxia-inducible factor). We analyzed 11 tumors from two distinct cohorts with TCEB1 mutations along with an expanded cohort to assess whether these should be considered an entity distinct from clear cell renal cell carcinoma and clear cell papillary renal cell carcinoma. All tumors were… CONTINUE READING
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