TCDD alters pituitary-adrenal function. I: Adrenal responsiveness to exogenous ACTH.

@article{Bestervelt1993TCDDAP,
  title={TCDD alters pituitary-adrenal function. I: Adrenal responsiveness to exogenous ACTH.},
  author={Lorelle L. Bestervelt and Yong Cai and David J. W. Piper and C J Nolan and Justin A. Pitt and W. N. Piper},
  journal={Neurotoxicology and teratology},
  year={1993},
  volume={15 6},
  pages={365-7}
}
Plasma ACTH concentrations in 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD)-treated rats (50 micrograms/kg; single, oral dose) were 2.1-, 2.1-, 2.9-, 1.7-, 1.5-, 2.0- and 3.0-fold greater than control values, respectively, at days 1, 3, 5, 7, 10, and 14. At days 1 and 5 plasma corticosterone concentrations were increased 5.1- and 8.0-fold, respectively; whereas, at days 10 and 14 they were depressed to values of 50% and 39% of controls, respectively. Adrenal glands were excised from rats… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 33 references

Reexamination of data used for establishing toxicity equivalence factors (TEFS) for chlorinated dihenzo-p-dioxins and dibenzofuran (CDDS and CDFS)

  • J. R. Olson, J. S. Bellin, D. G. Barnes
  • Chemosphere
  • 1989
1 Excerpt

The occurrence and fate of PCDDs and PCDFs in five bleached kraft pulp and paper mills

  • G. Amendola, D. Barna, +5 authors R. Whittemore
  • Chemosphere
  • 1989
1 Excerpt

Emissions of PCDDs and PCDFs from the pulp industry

  • S. E. Swanson, C. Rappe, J. Malmstrom, K. P. Kringstad
  • 1988
1 Excerpt

8-Tetrachlorodibenzp-p-dioxin induced alterations of rats adrenal and testicular steroidogenesis

  • C. A. Mebus
  • Thesis, University of Nebraska;
  • 1987
3 Excerpts

A . 2 , 3 , 7 , 8 - Tetrachlorodibenzp - p - dioxin induced alterations of rats adrenal and testicular steroidogenesis

  • C. Mebus
  • 1987

Perspective on hazardous waste problems related to dioxins

  • J. H. Exner
  • 1987
1 Excerpt

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