TCAB1: driving telomerase to Cajal bodies.

  title={TCAB1: driving telomerase to Cajal bodies.},
  author={Andrew S Venteicher and Steven E. Artandi},
  journal={Cell cycle},
  volume={8 9},
Telomerase supports the proliferation of progenitor cells and tumor cells by adding telomere repeats to chromosome ends. The low abundance and restricted expression pattern of telomerase have limited our knowledge of this important enzyme. A new telomerase protein, TCAB1, sheds light on the pathway that governs telomerase holoenzyme assembly and function in vivo. TCAB1 is a component of active telomerase and is required for the telomerase holoenzyme to accumulate in Cajal bodies and to elongate… CONTINUE READING