TCA Cycle-Mediated Generation of ROS Is a Key Mediator for HeR-MRSA Survival under β-Lactam Antibiotic Exposure

@inproceedings{Rosato2014TCACG,
  title={TCA Cycle-Mediated Generation of ROS Is a Key Mediator for HeR-MRSA Survival under β-Lactam Antibiotic Exposure},
  author={Roberto R. Rosato and Regina Fernandez and Liliana I. Paz and Christopher R. Singh and Adriana E. Rosato},
  booktitle={PloS one},
  year={2014}
}
Methicillin-resistant Staphylococcus aureus (MRSA) is a major multidrug resistant pathogen responsible for several difficult-to-treat infections in humans. Clinical Hetero-resistant (HeR) MRSA strains, mostly associated with persistent infections, are composed of mixed cell populations that contain organisms with low levels of resistance (hetero-resistant HeR) and those that display high levels of drug resistance (homo-resistant HoR). However, the full understanding of β-lactam-mediated HeR/HoR… CONTINUE READING
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