TCA Cycle-Mediated Generation of ROS Is a Key Mediator for HeR-MRSA Survival under β-Lactam Antibiotic Exposure

@article{Rosato2014TCACG,
  title={TCA Cycle-Mediated Generation of ROS Is a Key Mediator for HeR-MRSA Survival under β-Lactam Antibiotic Exposure},
  author={R. Rosato and R. Fernandez and L. Paz and C. Singh and A. Rosato},
  journal={PLoS ONE},
  year={2014},
  volume={9}
}
  • R. Rosato, R. Fernandez, +2 authors A. Rosato
  • Published 2014
  • Biology, Medicine
  • PLoS ONE
  • Methicillin-resistant Staphylococcus aureus (MRSA) is a major multidrug resistant pathogen responsible for several difficult-to-treat infections in humans. Clinical Hetero-resistant (HeR) MRSA strains, mostly associated with persistent infections, are composed of mixed cell populations that contain organisms with low levels of resistance (hetero-resistant HeR) and those that display high levels of drug resistance (homo-resistant HoR). However, the full understanding of β-lactam-mediated HeR/HoR… CONTINUE READING
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