TC1(C8orf4) correlates with Wnt/beta-catenin target genes and aggressive biological behavior in gastric cancer.

@article{Kim2006TC1C8orf4CW,
  title={TC1(C8orf4) correlates with Wnt/beta-catenin target genes and aggressive biological behavior in gastric cancer.},
  author={Byungsik Kim and Hyunlyoung Koo and Seunghee Yang and Seunghyun Bang and Yusun Jung and Youngmi Kim and Jungtae Kim and Chan Lee and Randall T. Moon and Kyuyoung Song and Inchul Lee},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2006},
  volume={12 11 Pt 1},
  pages={3541-8}
}
PURPOSE We have recently reported that TC1(C8orf4), a small protein present in vertebrates, functions as a novel regulator of the Wnt/beta-catenin pathway. TC1 up-regulates beta-catenin target genes that are implicated in the aggressive behavior of cancers. Our aim was to investigate the clinical and pathobiological relevance of TC1 in gastric cancer. EXPERIMENTAL DESIGN The expression of TC1 was analyzed using tissue microarray in correlation with clinicopathologic variables and beta-catenin… CONTINUE READING
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