TBX3 and its splice variant TBX3 + exon 2a are functionally similar.

@article{Hoogaars2008TBX3AI,
  title={TBX3 and its splice variant TBX3 + exon 2a are functionally similar.},
  author={Willem M. H. Hoogaars and Phil Barnett and Mercedes Rodr{\'i}guez and Danielle E W Clout and Antoon F. M. Moorman and Colin R Goding and Vincent M Christoffels},
  journal={Pigment cell & melanoma research},
  year={2008},
  volume={21 3},
  pages={
          379-87
        }
}
Tbx3, a member of the conserved family of T-box developmental transcription factors, is a transcriptional repressor required during cardiogenesis for the formation and specification of the sinoatrial node, the pacemaker of the heart. Both the TBX3 and the highly related TBX2 genes are also associated with several cancers, most likely as a consequence of their powerful anti-senescence properties mediated via suppression p14(Arf) and p21(CIP) expression. In melanoma, the TBX2 gene is frequently… CONTINUE READING

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