TBL1XR1 in physiological and pathological states.

  title={TBL1XR1 in physiological and pathological states.},
  author={Jian Yi Li and G. P. Daniels and Jing Tian Wang and Xinmin Zhang},
  journal={American journal of clinical and experimental urology},
  volume={3 1},
Transducin (beta)-like 1X related protein 1 (TBL1XR1/TBLR1) is an integral subunit of the NCoR (nuclear receptor corepressor) and SMRT (silencing mediator of retinoic acid and thyroid hormone receptors) repressor complexes. It is an evolutionally conserved protein that shares high similarity across all species. TBL1XR1 is essential for transcriptional repression mediated by unliganded nuclear receptors (NRs) and othe regulated transcription factors (TFs). However, it can also act as a… CONTINUE READING