TBL1–TBLR1 and β-catenin recruit each other to Wnt target-gene promoter for transcription activation and oncogenesis

Aberrant Wnt signalling promotes oncogenesis by increasing the nuclear accumulation of β-catenin to activate downstream target genes. However, the mechanism of β-catenin recruitment to the Wnt target-gene promoter, a critical step for removing the co-repressor complex, is largely unknown. Here, we report that transducin β-like protein 1 (TBL1) and its… CONTINUE READING