TBK1 directly engages Akt/PKB survival signaling to support oncogenic transformation.

  title={TBK1 directly engages Akt/PKB survival signaling to support oncogenic transformation.},
  author={Yi-Hung Ou and M. Angeles Fuster Torres and Rosalyn R. Ram and Etienne Formstecher and Christina L Roland and Tzuling Cheng and Rolf A Brekken and Ryan P Wurz and Andrew Tasker and Tony Polverino and Seng-Lai Tan and Michael A. White},
  journal={Molecular cell},
  volume={41 4},
The innate immune-signaling kinase, TBK1, couples pathogen surveillance to induction of host defense mechanisms. Pathological activation of TBK1 in cancer can overcome programmed cell death cues, enabling cells to survive oncogenic stress. The mechanistic basis of TBK1 prosurvival signaling, however, has been enigmatic. Here, we show that TBK1 directly activates AKT by phosphorylation of the canonical activation loop and hydrophobic motif sites independently of PDK1 and mTORC2. Upon mitogen… CONTINUE READING
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