TBK1 Protects Vacuolar Integrity during Intracellular Bacterial Infection

@article{Radtke2007TBK1PV,
  title={TBK1 Protects Vacuolar Integrity during Intracellular Bacterial Infection},
  author={Andrea L. Radtke and Laura M Delbridge and Siddharth Balachandran and Glen N Barber and Mary X. D. O'Riordan},
  journal={PLoS Pathogens},
  year={2007},
  volume={3},
  pages={629 - 637}
}
TANK-binding kinase-1 (TBK1) is an integral component of Type I interferon induction by microbial infection. The importance of TBK1 and Type I interferon in antiviral immunity is well established, but the function of TBK1 in bacterial infection is unclear. Upon infection of murine embryonic fibroblasts with Salmonella enterica serovar Typhimurium (Salmonella), more extensive bacterial proliferation was observed in tbk1(-/-) than tbk1(+/+) cells. TBK1 kinase activity was required for restriction… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 25 extracted citations

Autophagy in antimicrobial immunity.

Molecular cell • 2014
View 6 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 55 references

Recognition of microbial infection by Toll-like receptors.

Current opinion in immunology • 2003
View 6 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…