TBC1D1 Regulates Insulin- and Contraction-Induced Glucose Transport in Mouse Skeletal Muscle

@inproceedings{An2010TBC1D1RI,
  title={TBC1D1 Regulates Insulin- and Contraction-Induced Glucose Transport in Mouse Skeletal Muscle},
  author={Ding Ding An and Taro Toyoda and Eric B. Taylor and Haiyan Yu and Nobuharu Fujii and Michael F. Hirshman and Laurie J Goodyear},
  booktitle={Diabetes},
  year={2010}
}
OBJECTIVE TBC1D1 is a member of the TBC1 Rab-GTPase family of proteins and is highly expressed in skeletal muscle. Insulin and contraction increase TBC1D1 phosphorylation on phospho-Akt substrate motifs (PASs), but the function of TBC1D1 in muscle is not known. Genetic linkage analyses show a TBC1D1 R125W missense variant confers risk for severe obesity in humans. The objective of this study was to determine whether TBC1D1 regulates glucose transport in skeletal muscle. RESEARCH DESIGN AND… CONTINUE READING
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Genetic Disruption of Ampk Signaling Abolishes Both Contraction-and Insulin-Stimulated Tbc1d1 Phosphorylation and 14-3-3 Binding in Mouse Skeletal Muscle

  • C Pehmoller, JT Treebak, +5 authors JF Wojtaszewski
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