TAp73 isoforms antagonize Notch signalling in SH-SY5Y neuroblastomas and in primary neurones.

@article{Hooper2006TAp73IA,
  title={TAp73 isoforms antagonize Notch signalling in SH-SY5Y neuroblastomas and in primary neurones.},
  author={Claudie Hooper and Mahvash Tavassoli and J. Paul Chapple and Dafe Aghogho Uwanogho and Richard J Goodyear and Gerry Melino and Simon Lovestone and Richard Killick},
  journal={Journal of neurochemistry},
  year={2006},
  volume={99 3},
  pages={989-99}
}
p73, like Notch, has been implicated in neurodevelopment and in the maintenance of the mature central nervous system. In this study, by the use of reporter-gene assays, we demonstrate that C-promoter binding factor-1 (CBF-1)-dependent gene transcription driven by the Notch-1 intracellular domain (N1(ICD)) is potently antagonized by exogenously expressed transactivating (TA) p73 splice variants in SH-SY5Y neuroblastomas and in primary neurones. Time course analysis indicated that the inhibitory… CONTINUE READING
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