TAp63 suppresses metastasis through coordinate regulation of Dicer and miRNAs

@article{Su2010TAp63SM,
  title={TAp63 suppresses metastasis through coordinate regulation of Dicer and miRNAs},
  author={Xiaohua Su and Deepavali Chakravarti and Min Soon Cho and Lingzhi Liu and Young Jin Gi and Yu-Li Lin and Marco L. Leung and A El-naggar and Chad J Creighton and Milind B. Suraokar and Ignacio Wistuba and Elsa Renee Flores},
  journal={Nature},
  year={2010},
  volume={467},
  pages={986-990}
}
Aberrant expression of microRNAs (miRNAs) and the enzymes that control their processing have been reported in multiple biological processes including primary and metastatic tumours, but the mechanisms governing this are not clearly understood. Here we show that TAp63, a p53 family member, suppresses tumorigenesis and metastasis, and coordinately regulates Dicer and miR-130b to suppress metastasis. Metastatic mouse and human tumours deficient in TAp63 express Dicer at very low levels, and we… CONTINUE READING
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