TAp63 prevents premature aging by promoting adult stem cell maintenance.

  title={TAp63 prevents premature aging by promoting adult stem cell maintenance.},
  author={Xiaohua Su and Maryline Paris and Young Jin Gi and Kenneth Y. Tsai and Min Soon Cho and Yu-Li Lin and Jeff Biernaskie and Satrajit Sinha and Carol Prives and Larysa Halyna Pevny and F. D. Miller and Elsa Renee Flores},
  journal={Cell stem cell},
  volume={5 1},
The cellular mechanisms that regulate the maintenance of adult tissue stem cells are still largely unknown. We show here that the p53 family member, TAp63, is essential for maintenance of epidermal and dermal precursors and that, in its absence, these precursors senesce and skin ages prematurely. Specifically, we have developed a TAp63 conditional knockout mouse and used it to ablate TAp63 in the germline (TAp63(-/-)) or in K14-expressing cells in the basal layer of the epidermis (TAp63(fl/fl… CONTINUE READING
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